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Revealing Mechanisms of Functional Circuit Reconstruction Following Central Nervous System Injury

Prof. WANG Yiwen and Prof. LIU Kai Collaborated on Establishing an Intracranial Optic Tract Injury Model

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Prof. Wang Yiwen (first left, front row) from the Department of Electronic and Computer Engineering and the Department of Chemical and Biological Engineering, and Prof. Liu Kai (first right, front row) from the Division of Life Science and the Department of Chemical and Biological Engineering, along with his research team
Prof. Wang Yiwen (first left, front row) from the Department of Electronic and Computer Engineering and the Department of Chemical and Biological Engineering, and Prof. Liu Kai (first right, front row) from the Division of Life Science and the Department of Chemical and Biological Engineering, along with his research team [Download Photo]
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Prof. WANG Yiwen (Associate Professor of the Department of Electronic and Computer Engineering and the Department of Chemical and Biological Engineering) collaborated with Prof. LIU Kai (Professor of the Division of Life Science and the Department of Chemical and Biological Engineering) to establish an innovative intracranial pre-olivary pretectal nucleus (OPN) optic tract injury model (pre-OPN OTI), shedding light on crucial mechanisms of functional axonal rewiring following central nervous system injury.

Led by Prof. Liu, their study titled “Functional Optic Tract Rewiring via Subtype- and Target-Specific Axonal Regeneration and Presynaptic Activity Enhancement” was published in Nature Communications in March 2025. Other collaborating universities including the Chinese University of Hong Kong, City University of Hong Kong, and University of Science and Technology of China.

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